The Role of TRPM8 Channels in Oxidative Stress: TRPM8 and Oxidative Stress

Adem  AHLATCI

doi:10.5281/zenodo.11528520

Yazarlar

Adem AHLATCI Vocational School of Health Services, Van Yuzuncu Yil University, Van, Turkiye Yazar https://orcid.org/0000-0002-5109-2000

DOI:

https://doi.org/10.5281/zenodo.11528520

Anahtar Kelimeler:

Oxidative Stress; TRP Channels; TRPM8 Channel; Ca2+

Öz

The human body, with its innate sensitive ability, tries to keep the free radicals formed due to the natural production of the organism in a line known as oxidant-antioxidant balance. Disruption of this balance is called oxidative stress. The mitochondria constantly produce free oxygen radicals during the body's oxygen consumption. The free oxygen radicals released can be both harmful and beneficial. The role of oxidative stress in the pathogenesis of inflammatory, chronic, or degenerative diseases is known. Transient receptor potential (TRP) channels are non-selective cation channels essential in regulating calcium (Ca²⁺) concentration in various neuronal and non-neuronal cell types and tissues. It has been reported that excessive Ca²⁺ influx and oxidative stress caused by TRPM8 channel activation play a role in apoptosis. Therefore, the TRPM8 channel may help prevent oxidative stress-induced damage. Additionally, TRPM8 channels regulate Ca²⁺ cell homeostasis and function as a cellular sensor and cold temperature transducer. In this review, we examined the role of the TRPM8 cation channel in situations that may be caused by oxidative stress based on recent studies.

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