Scoliosis Research Trends and the Role of Artificial Intelligence: A Latent Dirichlet Allocation Analysis of Publications (2000–2024)

Authors

DOI:

https://doi.org/10.66588/NCMR.3.2.03

Keywords:

Latent dirichlet allocation, Scoliosis, Topic modeling, Artificial intelligence

Abstract

This study aimed to evaluate global research trends in scoliosis between 2000 and 2024 using latent Dirichlet allocation (LDA) topic modeling. English-language, peer-reviewed journal articles indexed in Scopus were analyzed using their titles, abstracts and keywords to identify dominant and relatively underrepresented research themes. The findings showed that surgery-related topics accounted for the largest thematic proportion of the scoliosis literature, whereas etiopathogenesis and genetic factors had limited structural representation. Artificial intelligence-related studies increased in recent years but remained primarily focused on radiological assessment, Cobb angle measurement and diagnostic applications. These results demonstrate an imbalance in the thematic distribution of scoliosis research; however, bibliometric frequency and topic proportion should not be interpreted as direct indicators of scientific quality or clinical importance. The findings may help researchers recognize areas that warrant further investigation, particularly etiological and genetic mechanisms. The application of artificial intelligence in genetics, precision medicine and treatment planning should be regarded as a potential direction for future research rather than an outcome directly demonstrated by the present analysis.

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References

Yaman O, Dalbayrak S. Idiopathic scoliosis. Turk Neurosurg. 2013. https://doi.org/10.5137/1019-5149.jtn.8838-13.0

Cheng JC, Castelein RM, Chu WC, Danielsson AJ, Dobbs MB, Grivas TB, Gurnett CA, Luk KD, Moreau A, Newton PO, Stokes IA, Weinstein SL, Burwell RG. Adolescent idiopathic scoliosis. Nat Rev Dis Primers. 2015;1(1). https://doi.org/10.1038/nrdp.2015.30

Shakil H, Iqbal ZA, Al-Ghadir AH. Scoliosis: Review of types of curves, etiological theories and conservative treatment. J Back Musculoskelet Rehabil. 2014;27(2):111–115. https://doi.org/10.3233/bmr-130438

De Sèze M, Cugy E. Pathogenesis of idiopathic scoliosis: A review. Ann Phys Rehabil Med. 2012;55(2):128–138. https://doi.org/10.1016/j.rehab.2012.01.003

Sayre L. On the Treatment of Spondylitis and Scoliosis by Partial Suspension to Improve the Position, and the Application of the Plaster of Paris Bandage to Retain It: Being the Account of a Demonstration before the Sixth International Medical Congress at Amsterdam, September, 1879. Glasgow Med J. 1879;12(11):344–348. https://pubmed.ncbi.nlm.nih.gov/30433176/

Kaelin AJ. Adolescent idiopathic scoliosis: indications for bracing and conservative treatments. Ann Transl Med. 2020;8(2):28. https://doi.org/10.21037/atm.2019.09.69

Outland T, Corn O. The Use of Parallel Grafts and of Two-Stage and Three-Stage Interlocking Grafts in The Treatment of Idiopathic Scoliosis. End Results in Forty-One Cases. J Bone Joint Surg. 1947;29(1):163–170.

Harrington PR. Treatment of scoliosis. Correction and internal fixation by spine instrumentation. J Bone Joint Surg Am. 1962;44-A:591–610. https://pubmed.ncbi.nlm.nih.gov/14036052/

Goldstein LA. Treatment of idiopathic scoliosis by Harrington instrumentation and fusion with fresh autogenous iliac bone grafts. J Bone Joint Surg Am. 1969;51(2):209–222. https://pubmed.ncbi.nlm.nih.gov/5767314/

Kiely PJ, Grevitt MP. Recent developments in scoliosis surgery. Curr Orthop. 2008;22(1):42–47.

Li J, Jiang P, An Q, Wang GG, Kong HF. Medical image identification methods: A review. Comput Biol Med. 2024;169:107777. https://doi.org/10.1016/j.compbiomed.2023.107777

McCarthy J, Minsky ML, Rochester N, Shannon CE. A Proposal for the Dartmouth Summer Research Project on Artificial Intelligence, August 31, 1955. AI Mag. 1955;27(4):12. https://doi.org/10.1609/aimag.v27i4.1904

Matheny ME, Whicher D, Thadaney Israni S. Artificial Intelligence in Health Care: A Report From the National Academy of Medicine. JAMA. 2020;323(6):509–510. https://doi.org/10.1001/jama.2019.21579

Fei J, Yong J, Hui Z, Yi D, Hao L, Sufeng M, Yilong W, Qiang D, Haipeng S, Yongjun W. Artificial Intelligence in Healthcare: Past, Present and Future. Stroke Vasc Neurol. 2017. https://pubmed.ncbi.nlm.nih.gov/29507784/

Dilsizian SE, Siegel EL. Artificial Intelligence in Medicine and Cardiac Imaging: Harnessing Big Data and Advanced Computing to Provide Personalized Medical Diagnosis and Treatment. Curr Cardiol Rep. 2014;16(1). https://doi.org/10.1007/s11886-013-0441-8

Bouton CE, Shaikhouni A, Annetta NV, Bockbrader MA, Friedenberg DA, Nielson DM, Sharma G, Sederberg PB, Glenn BC, Mysiw WJ, Morgan AG, Deogaonkar M, Rezai AR. Restoring cortical control of functional movement in a human with quadriplegia. Nature. 2016;533(7602):247–250. https://doi.org/10.1038/nature17435

Somashekhar S, Kumarc R, Rauthan A, Arun K, Patil P, Ramya Y. Abstract S6-07: Double blinded validation study to assess performance of IBM artificial intelligence platform, Watson for oncology in comparison with Manipal multidisciplinary tumour board – First study of 638 breast cancer cases. Gen Sess Abstr. 2017;77(4). https://doi.org/10.1158/1538-7445.sabcs16-s6-07

Wyatt JM, Booth GJ, Goldman AH. Natural Language Processing and Its Use in Orthopaedic Research. Curr Rev Musculoskelet Med. 2021. https://doi.org/10.1007/s12178-021-09734-3

Dewald CLA, Balandis A, Becker LS, Hinrichs JB, von Falck C, Wacker FK, Laser H, Gerbel S, Winther HB, Apfel-Starke J. Automated Classification of Free-Text Radiology Reports: Using Different Feature Extraction Methods to Identify Fractures of the Distal Fibula. RoFo Fortschr Geb Rontgenstr Nuklearmed. 2023;195(8):713–719. https://doi.org/10.1055/a-2061-6562

Altıntaş V, Albayrak M, Topal K. Kanser hastalığı ile ilgili paylaşımlar için Dirichlet ayrımı ile gizli konu modelleme. Gazi Univ Muhendislik-Mimarlik Fak Derg. 2021;36(4):2183–2196. https://doi.org/10.17341/gazimmfd.734730

Pérez J, Pérez A, Casillas A, Gojenola K. Cardiology record multi-label classification using latent Dirichlet allocation. Comput Methods Programs Biomed. 2018;164:111–119. https://doi.org/10.1016/j.cmpb.2018.07.002

Wu Y, Liu M, Zheng WJ, Zhao Z, Xu H. Ranking gene-drug relationships in biomedical literature using Latent Dirichlet Allocation. Pac Symp Biocomput. 2012:422–433. https://pubmed.ncbi.nlm.nih.gov/22174297/

Blei DM, Ng AY, Jordan MI. Latent dirichlet allocation. J Mach Learn Res. 2003;3:993–1022.

Kirilenko AP, Stepchenkova S. Facilitating topic modeling in tourism research: Comprehensive comparison of new AI technologies. Tour Manag. 2025;106:105007. https://doi.org/10.1016/j.tourman.2024.105007

Lee J, Kang JH, Jun S, Lim H, Jang D, Park S. Ensemble Modeling for Sustainable Technology Transfer. Sustainability. 2018;10(7):2278. https://doi.org/10.3390/su10072278

Gurcan F, Ozyurt O, Cagiltay NE. Investigation of Emerging Trends in the E-Learning Field Using Latent Dirichlet Allocation. Int Rev Res Open Distrib Learn. 2021;22(2):1–18. https://eric.ed.gov/?id=EJ1297810

Tao L, Zhou S, Tao Z, Wen K, Da W, Meng Y, Zhu Y. The publication trends and hot spots of scoliosis research from 2009 to 2018: a 10-year bibliometric analysis. Ann Transl Med. 2020;8(6):365. https://doi.org/10.21037/atm.2020.02.67

Guler S, Capkin S, Sezgin EA. The evolution of scoliosis publications: a detailed investigation of global outputs with bibliometric approaches. Turk Neurosurg. 2020. https://doi.org/10.5137/1019-5149.jtn.30216-20.2

Jiang X, Liu F, Zhang M, Hu W, Zhao Y, Xia B, Xu K. Advances in genetic factors of adolescent idiopathic scoliosis: a bibliometric analysis. Front Pediatr. 2024;11. https://doi.org/10.3389/fped.2023.1301137

VOSviewer, h.w.v.c., Access date: 24.12.2024.

von Heideken J, Iversen MD, Gerdhem P. Rapidly increasing incidence in scoliosis surgery over 14 years in a nationwide sample. Eur Spine J. 2017;27(2):286–292. https://doi.org/10.1007/s00586-017-5346-6

Pérez-Machado G, Berenguer-Pascual E, Bovea-Marco M, Rubio-Belmar PA, García-López E, Garzón MJ, Mena-Mollá S, Pallardó FV, Bas T, Viña JR, García-Giménez JL. From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis. Bone. 2020;140:115563. https://doi.org/10.1016/j.bone.2020.115563

Maqsood A, Frome DK, Gibly RF, Larson JE, Patel NM, Sarwark JF. IS (Idiopathic Scoliosis) etiology: Multifactorial genetic research continues. A systematic review 1950 to 2017. J Orthop. 2020;21:421–426. https://doi.org/10.1016/j.jor.2020.08.005

Vigneswaran HT, Grabel ZJ, Eberson CP, Palumbo MA, Daniels AH. Surgical treatment of adolescent idiopathic scoliosis in the United States from 1997 to 2012: an analysis of 20,346 patients. J Neurosurg Pediatr. 2015;16(3):322–328. https://doi.org/10.3171/2015.3.PEDS14649

Zhao T, Li Y, Dai Z, Zhang J, Zhang L, Shao H, Ge M, Kang Y, Xia C, Lenke LG. Bibliometric Analysis of the Scientific Literature on Adolescent Idiopathic Scoliosis. World Neurosurg. 2021;151:e265–e277. https://doi.org/10.1016/j.wneu.2021.04.020

Liu PC, Lu Y, Lin HH, Yao YC, Wang ST, Chang MC, Chien TW, Chou PH. Classification and citation analysis of the 100 top-cited articles on adult spinal deformity since 2011: A bibliometric analysis. J Chin Med Assoc. 2022;85(3):401. https://doi.org/10.1097/JCMA.0000000000000642

Hu R, Chen S, Chen X, Jiang Z, Du H. Adolescent idiopathic scoliosis research over the past 15 years: A bibliometric analysis of hotspots and emerging trends. Medicine (Baltimore). 2026;105(5):e47469. https://doi.org/10.1097/MD.0000000000047469

Bhandari M, Montori VM, Devereaux PJ, Wilczynski NL, Morgan D, Haynes RB, Hedges Team. Doubling the impact: publication of systematic review articles in orthopaedic journals. J Bone Joint Surg Am. 2004;86(5):1012–1016. https://pubmed.ncbi.nlm.nih.gov/15118046/

Zhang H, Huang C, Wang D, Li K, Han X, Chen X, Li Z. Artificial Intelligence in Scoliosis: Current Applications and Future Directions. J Clin Med. 2023;12(23):7382. https://doi.org/10.3390/jcm12237382

Goldman SN, Hui AT, Choi S, Mbamalu EK, Parsa Tirabady, Eleswarapu AS, Gomez JA, Alvandi LM, Fornari ED. Applications of artificial intelligence for adolescent idiopathic scoliosis: mapping the evidence. Spine Deform. 2024. https://doi.org/10.1007/s43390-024-00940-w

Wheeler JM, Cohen AS, Wang S. A Comparison of Latent Semantic Analysis and Latent Dirichlet Allocation in Educational Measurement. J Educ Behav Stat. 2023. https://doi.org/10.3102/10769986231209446

Ru L, Zheng H, Lian W, Zhao S, Fan Q. Knowledge mapping of idiopathic scoliosis genes and research hotspots (2002–2022): a bibliometric analysis. Front Pediatr. 2023;11. https://doi.org/10.3389/fped.2023.1177983

Taşkın R, Yılar S, Budak İ, Uğur F. Ultrasonography and the Reorientation of Developmental Hip Dysplasia Research: An NLP-NMF Trend Analysis (1980-2024). Eurasian J Med. 2026;58(2):1–9. https://doi.org/10.5152/eurasianjmed.2026.251249

Ma RT, Wu Q, Xu ZD, Zhang L, Wei YX, Gao Q. Exercise therapy for adolescent idiopathic scoliosis rehabilitation: a bibliometric analysis (1999–2023). Front Pediatr. 2024;11. https://doi.org/10.3389/fped.2023.1342327

Negrini S. Approach to scoliosis changed due to causes other than evidence: Patients call for conservative (rehabilitation) experts to join in team orthopedic surgeons. Disabil Rehabil. 2008;30(10):731–741. https://doi.org/10.1080/09638280801889485

Lonner BS, Ren Y, Yaszay B, Cahill PJ, Shah SA, Betz RR, Samdani AF, Shufflebarger HL, Newton PO. Evolution of Surgery for Adolescent Idiopathic Scoliosis Over 20 Years. Spine. 2018;43(6):402–410. https://doi.org/10.1097/brs.0000000000002332

Rigo M, Reiter Ch, Weiss HR. Effect of conservative management on the prevalence of surgery in patients with adolescent idiopathic scoliosis. Pediatr Rehabil. 2003;6(3-4):209–214. https://doi.org/10.1080/13638490310001642054

Sung S, Chae HW, Lee HS, Kim S, Kwon JW, Lee SB, Moon SH, Lee HM, Lee BH. Incidence and Surgery Rate of Idiopathic Scoliosis: A Nationwide Database Study. Int J Environ Res Public Health. 2021;18(15):8152. https://doi.org/10.3390/ijerph18158152

Lowe TG, Edgar M, Margulies JY, Miller NH, Raso VJ, Reinker KA, Rivard CH. Etiology of idiopathic scoliosis: current trends in research. J Bone Joint Surg Am. 2000;82(8):1157–1168. https://doi.org/10.2106/00004623-200008000-00014

Weiss HR, Goodall D. Rate of complications in scoliosis surgery – a systematic review of the Pub Med literature. Scoliosis. 2008;3(1). https://doi.org/10.1186/1748-7161-3-9

Zheng B, Zhu Z, Liang Y, Guo C, Liu H. A 20-year research trend analysis of the artificial intelligence on scoliosis using bibliometric methods. Front Pediatr. 2025;13:1531827. https://doi.org/10.3389/fped.2025.1531827

Schlösser TPC, van der Heijden GJMG, Versteeg AL, Castelein RM. How ‘Idiopathic’ Is Adolescent Idiopathic Scoliosis? A Systematic Review on Associated Abnormalities. PLoS One. 2014;9(5):e97461. https://doi.org/10.1371/journal.pone.0097461

Published

31-08-2026

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Research Article

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How to Cite

1.
Uğur F, Budak İbrahim, Albayrak M, Taşkin R, Ozer UE. Scoliosis Research Trends and the Role of Artificial Intelligence: A Latent Dirichlet Allocation Analysis of Publications (2000–2024). Neuro-Cell Mol Res. 2026;3(2):57-67. doi:10.66588/NCMR.3.2.03