TRPV1 channel-mediated apoptotic effects of Liquidambar Orientalis Miller balsam on gastric cancer cell line

Liquidambar Orientalis Miller Gum induces apoptosis in gastric cancer cells

Authors

DOI:

https://doi.org/10.5281/zenodo.14557674

Keywords:

Liquidambar orientalis, Balsam, TRPV1, Gastric cancer, Apoptosis.

Abstract

TRP channels play important roles in various cellular functions, such as proliferation, migration, invasion, and the ability to induce apoptosis in digestive system cancers. Liquidambar orientalis Miller Balsam (resin) is used in the treatment of skin problems, peptic ulcers and parasitic infections, as an antiseptic, as well as a supportive therapy for the treatment of some digestive tract cancers. In our study, we aimed to investigate the TRPV1 channel-mediated apoptotic effects of Liquidambar orientalis Miller balsam on HGC-27 Human Gastric Cancer Cell line.

HGC-27 cells were cultured and divided into three main groups as control, Liquidambar orientalis (balsam) and Liquidambar orientalis+capsazepine. The cells were incubated with Liquidambar orientalis along with a TRPV1 channel inhibitor and stimulator together. The effects of Liquidambar orientalis Miller balsam via TRPV1 channels were investigated in relation to apoptosis, mitochondrial depolarization, ROS and caspase-3 & -9 enzyme activations.

The levels of apoptosis in the Liquidambar orientalis group were significantly higher in cancer cells compared to the control group. TRPV1 channel stimulator administration resulted in significantly increased apoptosis, ROS, caspase-3 and -9 levels in the Liquidambar orientalis group compared to the Liquidambar orientalis+capsazepine group.

The apoptotic effects of Liquidambar orientalis Miiler balsam on gastric cancer cells have been shown to be associated with increased activation of TRPV1 channels due to increased intracellular reactive oxygen species. 

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Published

31-12-2024

How to Cite

1.
Akay İrem B, Günal MY, Övey İshak S. TRPV1 channel-mediated apoptotic effects of Liquidambar Orientalis Miller balsam on gastric cancer cell line: Liquidambar Orientalis Miller Gum induces apoptosis in gastric cancer cells. Neuro-Cell Mol Res. 2024;1(3):82-88. doi:10.5281/zenodo.14557674